Creatinine is a molecular structure, which is a product of muscle metabolism.This material is produced from creatine - an extremely important molecule for the energy supply of muscles.Every day in the human body about 2% of the creatine is converted to creatinine.The latter, in turn, is transported through the bloodstream to the kidneys, where it is filtered to form urine.Almost all creatinine is excreted by the kidneys.The amount of the substance during the day remains at the same level as human muscle mass is also not subject to change.
kidneys maintain the blood creatinine levels in the normal range.This means that when the kidney function is creatinine excretion in the urine.That is, the substance can be regarded as a kind of indicator of normal kidney function.If for any reason the renal function is impaired, the blood creatinine levels begin to rise.Too high levels of a given substance may be indicative of renal disease in different stages.That is why using standard biochemical blood analysis is n
number of creatinine can be determined using these three assays: Blood creatinine, creatinine clearance, and the ratio of nitrogen and creatinine.The most effective is considered to creatinine clearance.To determine this indicator will require samples of your blood and urine.Necessary to collect urine for 24 hours.The last test is performed to diagnose dehydration.
kidneys are not able to excrete and filter all creatinine, as there is a constant release of it into the blood, muscle tissue is viable.The plasma must be kept relatively stable level of creatinine, which is dependent on the age, characteristics and power of muscle activity.Therefore, allocate the maximum and minimum boundaries of creatinine standards that take into account all these factors and indicate normal functioning organs.
to results of biochemical blood test for levels of creatinine were more accurate, it is necessary to adhere to certain rules of the fence.Research is required to carry out in the morning on an empty stomach.Before collecting blood, avoid severe muscle stress and overheating or overcooling.One day before the analysis can not eat more than 200 grams of meat, especially beef, or other protein-rich foods.Also during this period is not recommended to drink coffee or strong tea.
Norma creatinine in the blood of the stronger sex is 74-110 mmol / l.Note that in men rate of the substance is higher than that of a similar age group of women.This is due to the peculiarities of lifestyle and differences in the functioning of organs and systems.In the process of creatinine metabolism is also affected by age-related characteristics.Most of the men in our time visiting gyms and to improve muscle performance by drugs, which is composed of creatine.This should be considered when evaluating the standards of creatinine in the blood of men.
most often as a result of biochemical analysis of blood face to the high concentration of this metabolite.It is important to correctly interpret the figures, given the possibility of physiological and pathological increase, age and gender.This state is called giperkreatinemiey.This pathology causes severe abnormalities in the body as creatinine itself has low toxicity.Its harmful effect on fabric is observed only in the case of sudden abnormalities its concentration.
not always increase in blood creatinine indicates kidney disease.Reasons for increasing its concentration often have "extrarenal" nature.Due to the unbalanced diet with a high content of proteins activates the synthesis of creatine, as a result, and creatinine.Another cause of this problem is a long fast.Because of the lack of nutrients the body from the outside begins to use protein as a backup energy source.Decay of this protein leads to an increase in creatinine concentration.Abundant internal bleeding (ulcers, tumors) may also cause activation creatinine synthesis, since vysokobelkovoj being "food" blood actively absorbed through the intestinal wall.By the natural increase in the concentration of blood components results and dehydration.
With increased creatinine in patients in most cases there are clinical signs of kidney damage, such as: high blood pressure, pain in the lower back, swelling, violation of diuresis by anuria (urine is not displayed) to polyuria (excretion of more than 2 liters of urineper day), as well as the presence of red blood cells in the urine and protein (hematuria and proteinuria).
Of course, in this case, many are interested in the question: how to reduce creatinine in the blood?First of all it should be noted that, without prior consultation with the doctor can not take any action.If a strong increase usually prescribe drugs that normalize the processes of protein breakdown.With a slight increase in creatinine should only revise their usual lifestyle and correct diet.It is advisable to consult a dietitian regarding proper nutrition.It recommended to reduce the consumption of meat and 200 g of 2-3 times a week.From fatty meat dishes better to refuse at all, preferring a rabbit, veal, white meat chicken or turkey.The necessary daily rate of protein is best to get out of dairy products, eggs, fish or nuts.It is necessary to include in the diet of more fruits and vegetables as well as cereals, boiled in water, and unleavened bread with bran.Do not forget about drinking regime.Every day you need to drink at least a liter of clean water.Drink water in the morning on an empty stomach and between meals, but it is not recommended during the meal.Also reduce blood creatinine level can be calculated by using the right exercise and proper rest.Very effective for relieving fatigue relaxing exercises, aromatherapy and yoga.
reason for the low level of creatinine in the blood may be a decrease in muscle mass caused by the disease, for example, such as muscular dystrophy.Low creatinine levels may be observed in a diet very low in protein or indicate certain types of severe liver disease.Also, this problem may occur when expressed violations kidney function arising from life-threatening infections, cancers, shock, low blood flow to the kidneys or urinary tract is blocked.The reasons for the low level of creatinine in the blood can also be heart failure, dehydration, and liver disease (cirrhosis).